238 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

    Juan Carlos Rengifo-Gonzalez et al.
    The RNA-mediated higher order assembly of TDP-43, a protein associated with neurodegenerative diseases, preserves its solubility by reducing the risk of multivalent interactions between low complexity domains.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural characterization of NrnC identifies unifying features of dinucleotidases

    Justin D Lormand et al.
    Dinucleotidases, specialized enzymes that catalyze the final step in RNA degradation, have evolved independently and repeatedly to fulfill essential roles in cell growth.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

    Gukui Chen et al.
    The diguanylate cyclase activity of SiaD is activated by its binding partner SiaC thourgh a dynamic mechanism of promoting the formation of active SiaD dimers.
    1. Cell Biology

    Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

    Lisa M Strong et al.
    The crystal structure of human WIPI2 bound to the ATG16L1 WIPI2-interacting region, combined with in vitro reconstitution and cellular autophagy assays, shows how the LC3 lipidation machinery is recruited in autophagy initiation.
    1. Cell Biology
    2. Developmental Biology

    Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

    Spencer R Katz et al.
    Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa et al.
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat et al.
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle

    Cameron Hill et al.
    The physiological contraction of skeletal muscle is controlled by structural changes in the thick filaments, establishing a new paradigm for developing potential treatments for muscle weakness.
    1. Evolutionary Biology

    A new Heterodontosaurus specimen elucidates the unique ventilatory macroevolution of ornithischian dinosaurs

    Viktor J Radermacher et al.
    A new specimen of Heterodontosaurus elucidates how ornithischian dinosaurs evolved a body plan substantially different from that of other dinosaurs and what these differences meant for their breathing.
    1. Ecology
    2. Microbiology and Infectious Disease

    A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA

    Chun-Yang Li et al.
    A novel dimethylsulfoniopropionate lyase was identified, which catalyzes dimethyl sulfide releasing by a new mechanism and is found in several bacterial lineages, revealing its important roles in global sulfur cycling.

Refine your results by:

Type
Research categories