1,841 results found
    1. Genes and Chromosomes

    A synthetic biology approach to probing nucleosome symmetry

    Yuichi Ichikawa et al.
    A novel system for expression of asymmetric nucleosomes in vivo enables mechanistic studies on histone modification readouts in the cell.
    1. Biochemistry
    2. Plant Biology

    A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

    Paulina Fuentes et al.
    A combination of chloroplast transformation with nuclear transformation and large-scale metabolic screening of supertransformed plant lines has enabled an entire biochemical pathway to be transferred from a medicinal plant to a high-biomass crop.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology

    Erik Henrich et al.
    As the function of membrane proteins is often influenced by its membrane environment the presented combinatorial approach is of great value for the investigation of membrane protein complexes in natural or even manipulated lipid bilayers.
    1. Biochemistry
    2. Computational and Systems Biology

    Synthetic Biology: How to make an oscillator

    Bas JHM Rosier, Tom FA de Greef
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    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Ecology
    2. Genomics and Evolutionary Biology

    Harbouring public good mutants within a pathogen population can increase both fitness and virulence

    Richard J Lindsay et al.
    Cooperation theory and a novel synthetic infection system provides a mechanistic understanding of why a seemingly successful disease management strategy can have devastating consequences for infected hosts.
    1. Cell Biology
    2. Computational and Systems Biology

    A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes

    Olga Loza et al.
    Localized feedback on Fa4-Ds1 boundary complexes underlies polarized distribution of Fat4 and Ds1 and gives rise to planar cell polarity.
    1. Developmental Biology and Stem Cells

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach et al.
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Mechanism of chiral proofreading during translation of the genetic code

    Sadeem Ahmad et al.
    Structural biology has elucidated the mechanism of a configuration-specific enzyme that decouples D-amino acids from the translational machinery and, therefore, is involved in the enforcement of homochirality during protein synthesis.

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