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Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.

The host-derived factors, pp32 and APRIL, interact with influenza viral RNA polymerase to support viral genomic RNA synthesis from complementary RNA.

Analysis of genomic DNA composition of surface plankton communities reveals a stable, ocean basin-scale plankton biogeography that emerges from the intertwined effects of environmental variations and currents.

A mutagenesis screen in budding yeast sheds light on dynein regulation and function, and reveals the molecular basis for disease in patients suffering from neuropathies caused by dynein dysfunction.

Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.

The C-terminus of A_2A receptor drives oligomer formation via an intricate network of disulfide bonds, hydrogen bonds, electrostatic interactions, and hydrophobic interactions, all of which are enhanced by depletion interactions.

A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.

Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.

Regulatory evolution allows paralogs to escape from strucural pleiotropy.

Antibody-based biologicals could provide an alternative approach to improve the diagnosis of Staphylococcus aureus biofilm-related infections.