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SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.

Transparent zebrafish, reveal the occurrence of foamy macrophages during an extracellular trypanosome infection and their association with an exacerbated inflammatory response.

Drosophila STING protein, or stimulator of interferon genes, has a direct but previously unknown role in the lipid metabolism.

Proteolytic events targeting histones can be harnessed to develop antibodies for neutrophil extracellular traps, improving researchers’ ability to distinguish these chromatin-based structures in human samples.

HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.

Genetic variants located in DNA repair genes and a reduced burden of somatic mutations protect the oldest living persons from age-related diseases, allowing an healthy aging phenotype.

Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in individuals with Down syndrome.

A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.

Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.

Genetic variation can have multiple effects on different phenotypic traits in organisms living in the natural environment.