Browse the search results

Page 3 of 531
    1. Developmental Biology

    Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

    Lauren LeBon et al.
    Fringe proteins modulate cis inhibitory, same-cell interactions between the Notch receptor and its ligands to control whether, and in which direction, cells can signal to one another.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

    Florian Heigwer et al.
    Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
    1. Structural Biology and Molecular Biophysics

    Deconstruction of the Ras switching cycle through saturation mutagenesis

    Pradeep Bandaru et al.
    Sequence conservation in Ras depends strongly on the biochemical network in which it operates, providing a framework for understanding the origin of global selection pressures on proteins.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

    Felipe Trajtenberg et al.
    The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases has been uncovered, through direct crystallographic observation of bona fide complexes between a histidine-kinase and its response regulator from Bacillus subtilise.
    1. Cell Biology
    2. Computational and Systems Biology

    Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins

    Alex X Lu et al.
    100,000s of images from different growth conditions and genetic backgrounds can be integrated into proteome-scale analysis.
    1. Human Biology and Medicine

    Integrative genomic analysis of the human immune response to influenza vaccination

    Luis M Franco et al.
    By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.
    1. Neuroscience

    A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity

    Anna G Hauswirth et al.
    A screen encompassing all kinases and phosphatases reveals that PI3K-cII, PI3K-cIII and Rab11-dependent recycling endosomes comprise a novel, postsynaptic 'signaling controller' that is part of an integrated, trans-synaptic signaling system necessary for presynaptic homeostatic plasticity.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Elastic instability during branchial ectoderm development causes folding of the Chlamydosaurus erectile frill

    Sophie A Montandon et al.
    Robust wrinkling pattern of the frilled dragon’s spectacular erectile ruff emerges from an elastic instability during homogeneous growth of the embryonic neck fold frustrated by its attachment to adjacent tissues.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach

    Guillermo Rodrigo, Mario A Fares
    Gene duplication is a useful strategy to reduce intrinsic noise in gene expression, which can provide a selective advantage in scenarios of cost-benefit analysis of expression.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution

    Scott M Coyle, Wendell A Lim
    A systems level reconstitution of H-Ras GTPase signaling reveals a rich space of tunable dynamic outputs and clarifies the consequences of oncogenic perturbations to signaling.