Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.

A meta-analysis of single-cell data reveals an advanced and conserved polarisation state of SPP1⁺ macrophages in multiple human fibrotic tissues.

The fruit fly estimates visual motion by incorporating ON-OFF asymmetric processing that only improves performance when stimuli have light-dark asymmetries matched to natural scenes.

The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.

Zeno SWATH MS, a novel data-independent acquisition technique in proteomics, which by facilitating sensitive detection in high-throughput experiments with low sample amounts, mitigates current bottlenecks of high-throughput proteomics.

The identification of 31 neuropeptide GPCRs in the sea anemone Nematostella vectensis provides a rich resource to study peptidergic signaling in cnidarians and suggests that cnidarian and bilaterian peptidergic systems diversified independent from each other from a few ancestral systems.

Calcium imaging is used to construct a model of Caenorhabditis elegans nervous system dynamics capable of predicting future behavioral switches on a trial by trial basis and across individual animals.

Unbiased and automatic annotation using structured prediction framework with efficiently built data-driven atlases is more accurate than registration-based methods for cell identifications in dense images and enables fast whole-brain analysis.

Cardiac organoids have potential as a tool used for identifying cell-free DNA as biomarkers for toxicity and severity of exposure outcomes.

An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.