Bone marrow adipocyte lipolysis is required for maintaining bone mass under conditions of energy deficiency and is necessary for myelopoiesis following caloric restriction and irradiation.
Sina B Kirchhofer, Victor Jun Yu Lim ... Moritz Bünemann
The molecular pattern underlying the interactions of opioids with their receptor determines whether membrane depolarization increases or decreases their response or even convert antagonists to agonists.
Holger Dannenberg, Hallie Lazaro ... Michael E Hasselmo
Spatial accuracy of grid cell firing correlates with the slope of the local field potential theta frequency vs. running speed relationship and integrates velocity signals over past time.
Larisa Venkova, Amit Singh Vishen ... Matthieu Piel
Whether deforming cells behave as elastic balls (deforming at constant volume) or as sponges (loosing volume as they deform) depends on how fast they change their shape, because the cell volume depends on the tension of the plasma membrane.
Curvature-preferring neurons in monkey V4 cluster into 0.5-mm patches, which highlights the importance of curvature detection in visual object recognition and the key functional role of V4 in this process.
In vitro and in vivo data show that C-natriuretic peptide is significant for increasing mitochondrial bioenergetics by cAMP-PKA pathway and improving cytoplasmic and nuclear maturation of maternally aged oocyte.
Nina Kirstein, Alexander Buschle ... Aloys Schepers
Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.
Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy
Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.
