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Page 4 of 466
    1. Neuroscience

    Competition between parallel sensorimotor learning systems

    Scott T Albert, Jihoon Jang ... Reza Shadmehr
    When a common error drives parallel implicit and explicit learning systems, increases in the explicit response will suppress implicit adaptation.
    1. Computational and Systems Biology

    Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

    Wen Yan, Saad Ansari ... Michael Shelley
    aLENS implements new parallel methods to resolve cytoskeletal assembly dynamics with high stability, physical consistency, and scalability.
    1. Computational and Systems Biology
    2. Developmental Biology

    Size control of the inner ear via hydraulic feedback

    Kishore R Mosaliganti, Ian A Swinburne ... Sean G Megason
    Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.
    1. Neuroscience

    Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

    Joshua B Burt, Katrin H Preller ... John D Murray
    Computational models of large-scale cortical dynamics, integrating gene expression mapping to pattern pharmacological modulation across cortex, capture inter-areal topographies of functional connectivity alterations induced by lysergic acid diethylamide, providing a framework for simulating effects of pharmacology in the human brain.
    1. Computational and Systems Biology

    Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria

    Roswitha Dolcemascolo, María Heras-Hernández ... Guillermo Rodrigo
    A mammalian protein with RNA recognition motifs can be used in bacteria to engineer post-transcriptional regulation.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

    Robert M Cooper, Lev Tsimring, Jeff Hasty
    Killing their neighbors allows bacteria to steal genes, including antibiotic resistance genes, which we observed under a microscope, quantified, modeled, and predicted potentially guiding strategies to combat it.
    1. Neuroscience

    A unifying mechanism governing inter-brain neural relationship during social interactions

    Wujie Zhang, Maimon C Rose, Michael M Yartsev
    Experiments and modeling suggest that a mechanism involving positive and negative feedback can explain the relationship between the neural activity of socially interacting bats.
    1. Computational and Systems Biology
    2. Developmental Biology

    Systems biology derived source-sink mechanism of BMP gradient formation

    Joseph Zinski, Ye Bu ... Mary C Mullins
    Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    High-throughput imaging and quantitative analysis uncovers the nature of plasmid positioning by ParABS

    Robin Köhler, Eugen Kaganovitch, Seán M Murray
    The ParABS system positions plasmids precisely within the cell but just below the threshold for oscillatory dynamics.
    1. Cell Biology
    2. Physics of Living Systems

    The positioning mechanics of microtubule asters in Drosophila embryo explants

    Jorge de-Carvalho, Sham Tlili ... Ivo A Telley
    Using cytosolic explants from Drosophila syncytial embryos combined with quantitative microscopy and perturbations, the mechanical forces separating Drosophila microtubule asters are revealed.