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    1. Cell Biology
    2. Plant Biology

    Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the moss Physcomitrella patens

    Elena Kozgunova et al.
    Lagging chromosomes in anaphase inhibits cytokinesis in plant cells.
    1. Microbiology and Infectious Disease

    Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

    Eva S Istvan et al.
    The malaria parasite Niemann-Pick Type C1-related protein is an important new antimalarial target.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

    Hideo Imamura et al.
    Genome sequencing reveals the evolution and epidemiology of Leishmania donovani in the Indian subcontinent, where epidemics have caused up to 30,000 deaths per year.
    1. Cell Biology

    Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery

    Daniel G Booth et al.
    The mitotic chromosome periphery is organised by the PP1 binding protein Ki-67 and contributes to nucleolar re-activation upon mitotic exit.
    1. Microbiology and Infectious Disease

    Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

    Andrew A Bridges, Bonnie L Bassler
    The global pathogen Vibrio cholerae monitors environmental polyamines to garner information about numbers of ‘self’ versus ‘other’ in the vicinity, and in response, to remain or disperse from biofilms.
    1. Cell Biology
    2. Neuroscience

    A feedback loop governs the relationship between lipid metabolism and longevity

    Nicole K Littlejohn et al.
    The dual control of adiposity and longevity emerges from a latent intestinal feedback loop which simultaneously augments fat loss and shields lifespan from the deleterious effects of continuous fat oxidation.
    1. Biochemistry and Chemical Biology

    Immunoproteasome functions explained by divergence in cleavage specificity and regulation

    Michael B Winter et al.
    Divergence in immunoproteasome substrate specificity and regulation from the constitutive proteasome impacts peptide cleavage quantity and the cellular capacity of the ubiquitin-proteasome system.
    1. Ecology
    2. Plant Biology

    How scent and nectar influence floral antagonists and mutualists

    Danny Kessler et al.
    Floral scent and nectar are highly variable in natural populations and both traits can influence outcrossing rates differently for different pollinators and increase future herbivory.
    1. Cancer Biology

    A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

    Haojie Jin et al.
    Combination of glutaminase inhibitor CB-839 and ASCT2 inhibitor V-9302 showed efficient antitumor effect against glutamine addicted liver cancer cells via glutathione depletion and reactive oxygen species (ROS) induction.
    1. Evolutionary Biology
    2. Plant Biology

    Negative regulation of conserved RSL class I bHLH transcription factors evolved independently among land plants

    Suvi Honkanen et al.
    An ancient and conserved genetic mechanism for cell differentiation is under distinct negative regulation in different lineages of land plants.