4,778 results found
    1. Cell Biology

    Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology

    Rohini R Nair et al.
    Prokaryotes use polycistronic messages for coordinated translation, whereas eukaryotic cells may achieve tunable protein synthesis by packaging monocistronic mRNAs into functional multiplexes via co-transcriptional interallelic coupling and non-canonical histone-H4 functions.
    1. Neuroscience

    Cortical tau deposition follows patterns of entorhinal functional connectivity in aging

    Jenna N Adams et al.
    Tau deposition in the aging brain follows patterns of functional connectivity that correspond to specific neural memory networks, and this relationship is strengthened in the presence of amyloid-β.
    1. Neuroscience

    The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

    Anders Martin Fjell et al.
    Volumetric lifespan change in subcortical structures follows fundamental principles of brain development, lifespan continuity, genetic organization, and age-invariant relationships to cognition.
    1. Immunology and Inflammation

    Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

    Bruce Zhang, David Gems
    The absence of helminth parasites in developed countries may be exacerbating pathological, age-associated inflammation, known as inflammaging, suggesting that helminth therapies could provide protection against age-related disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Dendritic trafficking faces physiologically critical speed-precision tradeoffs

    Alex H Williams et al.
    A simple model of active transport in neurons allows intracellular cargo to find sites of demand using only local signals, but predicts long delays in distributing cargo throughout a dendritic tree.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea

    Sinan Uğur Umu et al.
    Stochastic mRNA and non-coding RNA hybridisation has a major impact on protein expression.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

    Diane Marie Keeling et al.
    A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
    1. Ecology
    2. Evolutionary Biology

    Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

    Susanne RK Zajitschek et al.
    Sex differences in trait variability imply that both sexes should be included in biomedical trials, using sex-specific statistical power calculations.
    1. Medicine

    Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

    Danae E Zamboulis et al.
    Phase-specific mechanical and proteomic analyses reveal how tendon responds to its mechanical environment during postnatal development to meet functional requirements.
    1. Neuroscience

    Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards

    Sebastian Korb et al.
    Administration of dopamine and opioid receptor antagonists resulted in reduced reward anticipation (effort and increased negative facial reactions), but only administration of opioid antagonists resulted in reduced liking (facial reactions).

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