GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.
Postnatal KIF2A is a key regulator for axon/dendrite determination of developing dentate granule cells, and its loss developed apical axons in dentate molecular layer, broke hippocampal wiring, and induced temporal lobe epilepsy.
Excitatory cortical neurons with a shared developmental lineage are transcriptomically diverse and preferentially connect to each other vertically, across cortical layers, but not laterally within the same layer.
Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.
Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.