730 results found
    1. Neuroscience

    Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster

    César S Mendes, Imre Bartos ... Richard S Mann
    Novel imaging experiments suggest that fruit flies modify their neural circuitry for walking at slow, medium and fast speeds, and that proprioception is not essential for coordinated walking.
    1. Developmental Biology

    A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

    Huanhu Zhu, Huali Shen ... Min Han
    A lipid acts to promote the development of nematode worm larvae through activation of an enzyme complex called TORC1.
    1. Cell Biology
    2. Neuroscience

    Pharmacological brake-release of mRNA translation enhances cognitive memory

    Carmela Sidrauski, Diego Acosta-Alvear ... Peter Walter
    A compound that prevents stressors such as UV light and viral infection from downregulating protein synthesis inside cells improves memory performance in mice.
    1. Cell Biology

    Cavin-3 dictates the balance between ERK and Akt signaling

    Victor J Hernandez, Jian Weng ... Peter Michaely
    Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Hdac6 regulates Tip60-p400 function in stem cells

    Poshen B Chen, Jui-Hung Hung ... Thomas G Fazzio
    A normally cytoplasmic deacetylase, Hdac6, localizes to the nucleus in embryonic stem cells, where it regulates the essential Tip60-p400 chromatin remodeling complex.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Discovery of a metabolic alternative to the classical mevalonate pathway

    Nikki Dellas, Suzanne T Thomas ... Joseph P Noel
    A combination of phylogenetic and biochemical analyses suggest that some unexpected variations in the synthesis of isoprenoids may be widespread across all three domains of life.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A secreted Ustilago maydis effector promotes virulence by targeting anthocyanin biosynthesis in maize

    Shigeyuki Tanaka, Thomas Brefort ... Regine Kahmann
    A fungal effector secreted by the corn smut pathogen increases the virulence of the pathogen by elevating anthocyanin production and reducing lignification in maize.
  1. Cutting Edge: A network approach to mixing delegates at meetings

    Federico Vaggi, Tommaso Schiavinotto ... Attila Csikász-Nagy
    A network-based ‘speed dating’ approach can promote interactions between delegates at scientific meetings.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Super Spy variants implicate flexibility in chaperone action

    Shu Quan, Lili Wang ... James CA Bardwell
    Lab-evolved 'super Spy' chaperones show enhanced flexibility, which allows them to bind to and stabilize proteins more effectively than natural chaperones.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Repair of naturally occurring mismatches can induce mutations in flanking DNA

    Jia Chen, Brendan F Miller, Anthony V Furano
    The repair of spontaneous DNA damage can introduce mutators that lead to further genetic changes, which could underlie evolutionary change, disease and aging.

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