20 results found
    1. Structural Biology and Molecular Biophysics

    Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

    Kanchan Gupta et al.
    The tarantula toxins psalmotoxin and guangxitoxin have a similar concave surface for interacting with α-helices in voltage-gated and acid-sensing ion channels.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

    Chanhyung Bae et al.
    The structure of a bivalent double-knot tarantula toxin bound to the outer pore of the capsaicin receptor reveals a novel mode of toxin-channel recognition that has important implications for thermosensation.
    1. Structural Biology and Molecular Biophysics

    An external sodium ion binding site controls allosteric gating in TRPV1 channels

    Andres Jara-Oseguera et al.
    Allosteric gating in a transient receptor potential channel is modulated by external sodium ions and a tarantula toxin.
    1. Medicine

    Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

    Lorenzo Alamo et al.
    Mapping the locations of hypertrophic cardiomyopathy gene variants onto the three-dimensional structures of contractile proteins revealed that these disrupt protein interactions are critical for normal cardiac relaxation and efficient energy usage.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Engineering vanilloid-sensitivity into the rat TRPV2 channel

    Feng Zhang et al.
    Vanilloid sensitivity has been introduced into the TRPV2 channel, revealing that the gating and permeation properties of this enigmatic TRP channel are remarkably similar to the capsaicin receptor.
    1. Cell Biology

    Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

    William A Kronert et al.
    Integrative analysis of a Drosophila model of hypertrophic cardiomyopathy demonstrates that prolonged binding of the myosin cross-bridge to actin is a root cause of the disorder.
    1. Cell Biology

    Muscle Contraction: Too much of a good thing

    H Lee Sweeney
    A mutation that causes heart disease in humans increases the number of active myosin heads during contraction in the muscles of fruit flies, leading to the progressive dysfunction of the flight muscles and heart tube.
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    1. Structural Biology and Molecular Biophysics

    Binary architecture of the Nav1.2-β2 signaling complex

    Samir Das et al.
    X-ray crystallography reveals new conceptual insights into the location of the β2-subunit in the Nav channel signaling complex.
    1. Neuroscience

    A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

    Yangyu Wu et al.
    Three residues work together as a valve-like mechanism to control desensitization from pre-open and open states in the ion channels ASIC1a, ASIC2a, and ASIC3.

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