6,264 results found
    1. Neuroscience

    Foveal vision anticipates defining features of eye movement targets

    Lisa M Kroell, Martin Rolfs
    Before a saccadic eye movement to a location in the visual periphery, human observers' foveal vision becomes more sensitive to the features defining the eye movement target, anticipating information that will soon be fixated in a retinotopic reference frame.
    1. Cancer Biology
    2. Developmental Biology

    Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

    Inês M Tenente, Madeline N Hayes ... David M Langenau
    MYF5 and MYOD regulate rhabdomyosaroma growth and tumor-propagating potential, acting more than as passive markers retained from the target cell-of-origin during transformation.
    1. Computational and Systems Biology
    2. Neuroscience

    Towards deep learning with segregated dendrites

    Jordan Guerguiev, Timothy P Lillicrap, Blake A Richards
    A multi-compartment spiking neural network model demonstrates that biologically feasible deep learning can be achieved if sensory inputs and higher-order feedback are received by different dendritic compartments.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Current CRISPR gene drive systems are likely to be highly invasive in wild populations

    Charleston Noble, Ben Adlam ... Martin A Nowak
    If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
    1. Neuroscience

    Distinct roles of forward and backward alpha-band waves in spatial visual attention

    Andrea Alamia, Lucie Terral ... Rufin VanRullen
    Covert visual attention modulates alpha-band traveling waves propagating from frontal to occipital regions in both hemispheres, yet it modulates waves propagating in the opposite direction (occipital to frontal) only in the presence of visual stimulation.
    1. Biochemistry and Chemical Biology

    Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes

    Cristian A Lasagna-Reeves, Maxime WC Rousseaux ... Huda Y Zoghbi
    Building on previous work (Lasagna-Reeves et al., 2015) it is shown that polyglutamine ATXN1 oligomers propagate locally in SCA1 mice, and that passive immunotherapy targeting soluble oligomers can lead to an improvement in motor coordination and a modest increase in life span.
    1. Neuroscience

    Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex

    Cheng Tang, Roger Herikstad ... Shih-Cheng Yen
    The evidence of subspace computation in the lateral prefrontal cortex provides insights into the neural mechanisms underlying cognitive flexibility and interference between different cognitive processes.
    1. Neuroscience

    anTraX, a software package for high-throughput video tracking of color-tagged insects

    Asaf Gal, Jonathan Saragosti, Daniel JC Kronauer
    anTraX is an algorithm and software package that facilitates automated analyses of insect social behavior in species and experimental settings that are not accessible with currently existing technology.
    1. Structural Biology and Molecular Biophysics

    PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

    Sergey Gorelick, Genevieve Buckley ... Alex de Marco
    The PIE-scope resolves the limitations in correlative cryo-focused ion beam milling by adding robustness and ease of use to the workflow.
    1. Neuroscience

    Humans can efficiently look for but not select multiple visual objects

    Eduard Ort, Johannes Jacobus Fahrenfort ... Christian NL Olivers
    During search for multiple targets, individuals can efficiently prepare to select multiple target objects simultaneously, but the actual selection of those objects from the sensory input is limited.

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