4,918 results found
    1. Ecology
    2. Evolutionary Biology

    Understanding the evolution of multiple drug resistance in structured populations

    David V McLeod, Sylvain Gandon
    The evolution of multidrug resistance can be most easily understood by focusing upon the dynamical equations of linkage disequilibrium.
    1. Developmental Biology
    2. Evolutionary Biology

    Early maternal loss leads to short- but not long-term effects on diurnal cortisol slopes in wild chimpanzees

    Cédric Girard-Buttoz et al.
    Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.
    1. Cell Biology
    2. Medicine

    Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

    Srinu Tumpara et al.
    Finding that circulating Z alpha-1 antitrypsin polymers, a feature of ZZ AAT deficiency, lower the expression of CX3CR1 on peripheral blood mononuclear cells encourages more detailed analyses on different circulating misfolded proteins and their role on immune cell surveillance/function.
    1. Computational and Systems Biology
    2. Developmental Biology

    Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

    Emanuel Cura Costa et al.
    Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Biosynthesis of a sulfated exopolysaccharide, synechan, and bloom formation in the model cyanobacterium Synechocystis sp. strain PCC 6803

    Kaisei Maeda et al.
    A potentially useful cyanobacterial sulfated exopolysaccharide and its biosynthesis and regulation genes, which contribute to the laboratorial bloom formation, are elucidated for the first time among prokaryotes.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang et al.
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Biochemistry and Chemical Biology

    Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

    M'Lynn E Fisher et al.
    Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex

    Alexander R Leydon et al.
    The TPL corepressor binds to the core mediator complex through MED21 to inhibit transcription while simultaneously priming repressed genes for rapid reactivation.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Cell Biology

    Micron-scale geometrical features of microtubules as regulators of microtubule organization

    Nandini Mani et al.
    Micron-scale geometrical features of individual microtubule polymers and polymer networks encode information that guides the self-organization of microtubules into specialized structures for diverse cellular functions such as cell division and signaling in eukaryotic cells.

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