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Page 2 of 507
Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification
Rodrigo M Young et al.
Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation
Marieke MB Hoekstra et al.
The temperature-sensitive protein CIRBP contributes to the effect of sleep loss on the molecular circadian clock.
Chromosomes and Gene Expression
Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling
Evanthia Zacharioudaki et al.
Depleting Mi-2 in the progeny of neural stem cells prevents normal enhancer decommissioning so that they become sensitive to Notch activity and re-acquire stem cell properties.
Quantitative uniqueness of human brain evolution revealed through phylogenetic comparative analysis
Ian F Miller et al.
The exceptionally large size of the human brain is the result of accelerating evolution towards larger brains in hominins, but is not the product of neocortical expansion.
Human Biology and Medicine
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
King Faisal Yambire et al.
Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.
A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain
Nicolas P Andrews et al.
A coherent pipeline converts conventional monoclonal antibodies into recombinant form that results in an IgG subclass switch, greatly expanding their utility for multiplex labeling.
Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses
Laura Hanson et al.
Experimental and computational models reveal how parallel 'core' mechanisms shape direction selectivity at the dendrites of starburst amacrine cells and ganglion cells in the mouse retina.
Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci
Sonia Q Sen et al.
Spatial factors generate neuroblast-specific open chromatin, thereby biasing the subsequent binding of transcription factors to produce neuroblast-specific neurons.
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
Structure of a bacterial ATP synthase
Hui Guo et al.
Construction of a first atomic model for an intact bacterial ATP synthase allows for a structural understanding of the roles of individual amino acids in the mechanism of ATP synthesis.
Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase
Sven Schenk et al.
A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.
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