3,122 results found
    1. Evolutionary Biology
    2. Cancer Biology

    Evolutionary dynamics of cancer in response to targeted combination therapy

    Ivana Bozic et al.
    A study that models the evolution of drug resistance in tumors reveals that drugs are more effective when given in combination than sequentially, and that cure is much more likely when the drugs target different pathways.
    1. Cancer Biology

    KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

    Elsa B Krall et al.
    Loss of KEAP1 modulates sensitivity to targeted therapies in lung cancer.
    1. Cancer Biology

    Breast Cancer: Targeting mutant estrogen receptors

    Suzanne E Wardell et al.
    A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
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    1. Cancer Biology

    Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways

    S Michael Rothenberg et al.
    SOX2 causes resistance to anti-EGFR therapies in EGFR-mutant lung cancer.
    1. Cancer Biology
    2. Developmental Biology

    Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

    Carla S Verissimo et al.
    Libraries of patient-derived tumor organoids are a reliable and scalable model system that can help identify and optimize targeted therapies in a pre-clinical setting.
    1. Cell Biology
    2. Cancer Biology

    MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

    Yubao Wang et al.
    Maternal embryonic leucine zipper kinase (MELK) is a new anti-cancer target that is highly selective for basal-like breast cancer.
    1. Cancer Biology

    BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

    Harina Vin et al.
    The cancer drug vemurafenib has potent off-target effects on JNK signaling that contribute to the development of squamous cell carcinomas in humans and in mice.
    1. Cancer Biology

    Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

    Simone Lieb et al.
    Targeting Werner syndrome helicase might constitute a novel opportunity for the treatment of a clinically defined subset of patients harboring MSI-H/MMR-deficient tumors.

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