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    1. Neuroscience

    Perception of microstimulation frequency in human somatosensory cortex

    Christopher L Hughes, Sharlene N Flesher ... Robert A Gaunt
    Increasing microstimulation frequency in some regions of the human somatosensory cortex decreased the perceived intensity and evoked specific percepts, providing insight into cortical organization and sensory feedback approaches for brain–computer interfaces.
    1. Cell Biology
    2. Neuroscience

    MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

    Andrea Toledo, Mathieu Letellier ... Olivier Thoumine
    MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

    Leon Y Chan, Christopher F Mugler ... Karsten Weis
    Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Molecular basis of the PIP2-dependent regulation of CaV2.2 channel and its modulation by CaV β subunits

    Cheon-Gyu Park, Wookyung Yu, Byung-Chang Suh
    The anchoring properties of CaV β2 subunits to the plasma membrane determine the biophysical states of CaV2.2 channels by regulating PIP2 coupling to the nonspecific phospholipid-binding site in the I–II loop.
    1. Evolutionary Biology

    Selection and the direction of phenotypic evolution

    François Mallard, Bruno Afonso, Henrique Teotónio
    Predicting multivariate phenotypic evolution.
    1. Ecology

    Linking spatial patterns of terrestrial herbivore community structure to trophic interactions

    Jakub Witold Bubnicki, Marcin Churski ... Dries PJ Kuijper
    The spatial interactions between humans, large carnivores and herbivores cascade down in a complex but predictable way to lower trophic levels affecting regeneration of tree species in a temperate forest.
    1. Neuroscience

    Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

    Benjamin R Kop, Yazan Shamli Oghli ... Lennart Verhagen
    Realizing the clinical and neuroscientific potential of transcranial ultrasonic stimulation (TUS) requires careful control of the peripheral auditory confounds that underlie previously reported online motor inhibitory effects.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Recovering mixtures of fast-diffusing states from short single-particle trajectories

    Alec Heckert, Liza Dahal ... Xavier Darzacq
    Tracking proteins in live cells is challenging due to technical limitations and biological complexity, but approaches based in Bayesian nonparametrics stand a decent chance at recovering a target protein's dynamic profile from noisy data.
    1. Neuroscience

    Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

    Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell
    RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

    Jinmi Choi, Kseniia Lysakovskaia ... Patrick Cramer
    Temporal changes in genome-wide enhancer transcription activity during a transdifferentiation event reveal additive and synergistic enhancer cooperation.