The UA-dinucleotide ratio in UTRs is negatively correlated with RNA stability both in the massively parallel reporter assay and in vivo, and is prevalent in fast-turnover genes.

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

A deep mutational scan of MET kinase domain variants reveals resistance and sensitizing mutations for 11 inhibitors, providing a mutation-specific reference for precision therapies and drug development.

Genetic, ultrastructural, multi-omics, and biochemical tools reveal VirR as a central scaffold in Mycobacterium tuberculosis cell envelope remodelling, critical for extracellular vesicle production.

Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.