1,561 results found
    1. Cancer Biology
    2. Genetics and Genomics

    Gene Fusion: Decoding the identity of rare tumors

    Qingchen Yuan, Prabhjot Kaur, Olga A Guryanova
    Solitary fibrous tumors have gene expression signatures similar to those of neuroendocrine tumors.
    Version of Record
    Insight
    1. Medicine

    Insights from full-text analyses of the Journal of the American Medical Association and the New England Journal of Medicine

    Moustafa Abdalla, Mohamed Abdalla ... Scott H Podolsky
    Historical analysis of nearly half-a-million articles from the Journal of the American Medical Association and the New England Journal of Medicine since their inception frames the shifting scientific, material, ethical, and epistemic underpinnings of medicine over time, including today.
    1. Epidemiology and Global Health

    Cancer risk perception and physician communication behaviors on cervical cancer and colorectal cancer screening

    Diane M Harper, Madiha Tariq ... Ken Resnicow
    The physician involving the woman as much as she wants in her health care is significantly associated with up-to-date dual cervical and colorectal cancer screening compared to being up to date in only cervical cancer screening.
    1. Genetics and Genomics

    Allele-specific gene-editing approach for vision loss restoration in RHO-associated retinitis pigmentosa

    Xiaozhen Liu, Jing Qiao ... Liping Yang
    The allele-specific gene-editing drug is expected to make RHO-T17M-associated retinitis pigmentosa therapy a reality.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

    Yosuke Yoneyama, Peter Lanzerstorfer ... Shin-Ichiro Takahashi
    IRS-1, a canonical signaling mediator of IGF-I receptor, serves as an endocytic regulator of IGF-I receptor to facilitate the sustained IGF signaling.
    1. Neuroscience

    Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

    Pablo M Casillas-Espinosa, Alison Anderson ... Terence J O'Brien
    Sodium selenate is the first treatment with persistent disease-modifying effects reducing seizures and improving cognitive deficits, in chronically epileptic and drug-resistant TLE animals.
    1. Cell Biology
    2. Computational and Systems Biology

    Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

    Anil Korkut, Weiqing Wang ... Chris Sander
    Data-driven systems biology models of signaling predict cellular response to untested perturbations and can nominate drug combinations to overcome drug resistance in cancer cells.
  1. Illustration by Vivid Biology

    COVID-19 and the Research Community: It is time for open access in clinical care

    Edy Kim
    A healthcare center widely sharing its internal guidelines on how to treat COVID-19 patients “just wasn’t done.” As the pandemic raged at a Boston hospital, the next generation of clinical leaders pushed for change.
    1. Epidemiology and Global Health

    Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study

    Gayathri Nagaraj, Shaveta Vinayak ... Dimpy P Shah
    Sociodemographic (age, race/ethnicity) and clinical (Eastern Cooperative Oncology Group performance status, pre-existing comorbidities, and active and progressing cancer) risk factors were associated with worse COVID-19 outcomes in patients with breast cancer.
    1. Epidemiology and Global Health

    A review of HPV and HBV vaccine hesitancy, intention, and uptake in the era of social media and COVID-19

    Emily K Vraga, Sonya S Brady ... Shalini Kulasingam
    A review of the current empirical literature underscores the need for longitudinal research examining potential spillover effects between hesitancy, intention, or uptake for the COVID vaccine and HPV and HBV vaccines, especially to account for social media misinformation.

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