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    1. Microbiology and Infectious Disease

    Apoptotic neurodegeneration in whitefly promotes the spread of TYLCV

    Shifan Wang et al.
    A plant virus, Tomato yellow leaf curl virus, manipulates the host preference of the vector insect whitefly to promote its transmission by inducing caspase-dependent apoptotic neurodegeneration in vector's brain.
    1. Human Biology and Medicine

    Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

    Tiziana Squillaro et al.
    An update on the role of lncRNAs in adipogenesis and adipose tissue function, aimed at promoting the identification of new drug targets for obesity and metabolic diseases.
    1. Epidemiology and Global Health

    Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults

    Flavia Camponovo et al.
    Malaria pre-exposed volunteers exhibit large breadth of humoral immune responses, with strong variation between individuals, which might compromise vaccine-induced humoral immune response due to natural imprinting.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance

    Christopher D Goodman et al.
    Actinonin kills malaria parasites by targeting the apicoplast-associated metalloprotease FTSH1.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity

    Pengxiang Fan et al.
    A nightshade family gene cluster creates phenotypic novelty in trichome defensive metabolites via evolution of lipid metabolic enzymes.
    1. Cancer Biology

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Zeyad D Nassar et al.
    DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

    Sebastian I Arriola Apelo et al.
    Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.
    1. Epidemiology and Global Health

    The effect of climate change on yellow fever disease burden in Africa

    Katy AM Gaythorpe et al.
    Analysis of yellow fever burden in Africa illustrates the need to consider the effect of a changing climactic conditions when planning future intervention strategies.
    1. Human Biology and Medicine
    2. Neuroscience

    Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

    David Cabañero et al.
    Operant drug self-administration in a mouse model of neuropathic pain reveals pain-relieving effects of a cannabinoid CB2 receptor agonist that are mediated through CB2 receptors of neurons and lymphocytes.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

    Charlotte F Kelley et al.
    In vitro reconstitution of the core focal adhesion proteins talin and vinculin with actin reveals lipid-dependent release of autoinhibition.