187 results found
    1. Human Biology and Medicine
    2. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai et al.
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.
    1. Developmental Biology

    Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis

    Wei Zhao et al.
    Inducing presomitic mesoderm (PSM)-fated ES cells clarified that Ripply2 directly interacts with Tbx6 and degrades Tbx6 in proteasome-ubiquitin pathway by recruiting the 26S proteasome, which is a PSM-specific event to define the segment border during mouse somitogenesis.
    1. Developmental Biology
    2. Evolutionary Biology

    A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

    Glenda Comai et al.
    Tbx1-Isl1-Met defines a unique genetic hierarchy that regulates esophagus myogenesis and patterning in the mouse.
    1. Developmental Biology
    2. Human Biology and Medicine

    T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

    Uchenna Emechebe et al.
    The transcription and splicing factor T-box3 is present in primary cilia, regulates multiple aspects of limb development, and interacts with members of the protein complex required for the stability and processing of the Gli3 transcription factor.
    1. Developmental Biology

    Specialized impulse conduction pathway in the alligator heart

    Bjarke Jensen et al.
    A specialized conduction pathway for the electrical impulse in the heart, previously thought to be associated with the endothermic mammals and birds only, is also present in the ectothermic crocodiles.
    1. Developmental Biology
    2. Genetics and Genomics

    Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species

    Eric T Domyan et al.
    Feathered feet of pigeons and chickens result from a partial molecular and morphological transformation of legs to a wing-like identity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

    Xinan H Yang et al.
    Transcription-factor-dependent noncoding RNA transcription illuminates components of a transcription-factor-dependent gene regulatory network that includes enhancer-associated long noncoding RNAs and is necessary for cardiac rhythm.
    1. Cell Biology
    2. Developmental Biology

    Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

    Pavan Kumar P et al.
    A novel master regulatory mechanism of cell proliferation and senscence employs the lncRNA UCA1 and a CAPERα/TBX3 corepressor.
    1. Developmental Biology

    Genetic Diseases: Many ways to break a heart

    Megan Rowton, Ivan P Moskowitz
    Insight
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    1. Human Biology and Medicine

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.

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