283 results found
    1. Cell Biology

    Telocytes regulate macrophages in periodontal disease

    Jing Zhao, Anahid A Birjandi ... Paul Sharpe
    A poorly understood cell type, the telocyte, is shown to regulate macrophages.
    1. Cell Biology
    2. Developmental Biology

    Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

    Arul Subramanian, Lauren Fallon Kanzaki ... Thomas Friedrich Schilling
    Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis

    Linda Grigoraki, Xavier Grau-Bové ... Hilary Ranson
    Delineation of the cuticular hydrocarbon biosynthetic pathway in malaria vectors is a key step in understanding how mosquitoes adapt to anthropogenic change and vector control interventions.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji, Kristen L Howell ... Alice H Huang
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

    Hyeogsun Kwon, Mubasher Mohammed ... Ryan C Smith
    Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.
    1. Stem Cells and Regenerative Medicine

    Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype

    Antonion Korcari, Anne EC Nichols ... Alayna E Loiselle
    Age-related tendon degeneration is initiated by loss of tenocytes associated with synthesis of high-turnover rate proteoglycans and glycoproteins.
    1. Cell Biology
    2. Developmental Biology

    Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

    Keiichiro Koiwai, Takashi Koyama ... Ryuji Kawano
    Single-cell mRNA sequencing on hemocytes of penaeid shrimp revealed six types of hemocytes, type markers, differentiation pathways, and different immune roles among these subpopulations based on their transcriptional profiles.
    1. Developmental Biology
    2. Immunology and Inflammation

    Developmental Immunology: An atlas for hemocytes in an insect

    Samuel Liegeois, Dominique Ferrandon
    Single-cell RNA sequencing has revealed distinct subpopulations of hemocytes in fruit fly larvae.
    Version of Record
    Insight
    1. Cell Biology
    2. Developmental Biology

    Tgfβ signaling is critical for maintenance of the tendon cell fate

    Guak-Kim Tan, Brian A Pryce ... Ronen Schweitzer
    Conditional deletion of TGFβ signaling results in tenocyte dedifferentiation in vivo demonstrating a key role for TGFβ signaling in the maintenance of the tendon cell fate.
    1. Microbiology and Infectious Disease

    Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium

    Ana Beatriz F Barletta, Banhisikha Saha ... Carolina Barillas-Mury
    Toll signaling modulates hemocyte differentiation into the megacyte lineage and their recruitment to the midgut greatly enhances mosquito immunity against Plasmodium.

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