288 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Cancer-associated TERT promoter mutations abrogate telomerase silencing

    Kunitoshi Chiba et al.
    TERT promoter mutations impair TERT silencing upon cellular differentiation and are sufficient to facilitate cellular immortalization without additional tumor selected changes, explaining why they are associated with a very specific tumor spectrum.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of human TERT elements necessary for telomerase recruitment to telomeres

    Jens C Schmidt et al.
    The TEN-domain of human telomerase mediates the direct interaction with TPP1 to drive telomerase recruitment to telomeres.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of nucleotide selection by telomerase

    Matthew A Schaich et al.
    The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.
    1. Chromosomes and Gene Expression

    Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

    Mélanie Criqui et al.
    Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes

    Robert Alexander Wu et al.
    New labeling approaches for single-molecule fluorescence microscopy detect the monomeric catalytic subunit of human telomerase within cellular holoenzyme and minimal active recombinant enzyme.
    1. Evolutionary Biology

    Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons

    Bastien Saint-Leandre et al.
    Evolution strictly preserves telomere stability but rapidly diversifies telomere length regulation in Drosophila.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

    Rosa Maria Porreca et al.
    TRF1 suppresses replication fork stalling, which triggers break induced replication at telomeres associated with DNA damage response, alteration in the telomere chromatin environment, and re-localisation of telomeres to PML bodies.
    1. Chromosomes and Gene Expression

    The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis

    Roland Ivanyi-Nagy et al.
    A messenger RNA coding for the histone 1.2 protein negatively regulates telomere elongation by interacting with human telomerase RNA.
    1. Epidemiology and Global Health
    2. Medicine

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin et al.
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Genetics and Genomics

    Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

    Niko Välimäki et al.
    Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.

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