The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.

The TEN-domain of human telomerase mediates the direct interaction with TPP1 to drive telomerase recruitment to telomeres.

New labeling approaches for single-molecule fluorescence microscopy detect the monomeric catalytic subunit of human telomerase within cellular holoenzyme and minimal active recombinant enzyme.

A new tool that allows specific subpopulations of telomerase RNAs in vivo forces a thorough revision of the telomerase maturation pathway and suggests a new function for Mex67.

The Cajal body chaperone TCAB1 and scaffold protein Coilin are not required for telomerase activity in human cells.

Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.

TERT promoter mutations impair TERT silencing upon cellular differentiation and are sufficient to facilitate cellular immortalization without additional tumor selected changes, explaining why they are associated with a very specific tumor spectrum.

Comprehensive analysis of telomere maintenance from transcriptomic, epigenetic, and loss-of-function profiles of cancer cell lines elucidates features of telomere regulation in cancer.

A messenger RNA coding for the histone 1.2 protein negatively regulates telomere elongation by interacting with human telomerase RNA.

Cystathionine-β-synthase is a novel metabolic regulator of AKT-induced senescence and a potential tumor suppressor in gastric cancer pathogenesis which can be harnessed to target PI3K/AKT-driven cancers.