477 results found
    1. Chromosomes and Gene Expression

    Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy

    Carmina Lichauco, Eric J Foss ... Antonio Bedalov
    Precocious ribosomal DNA replication in sir2 mutants requires Fun30.
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
    Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
    1. Genetics and Genomics

    SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

    Kira Breunig, Xiufen Lei ... Luiz OF Penalva
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    • Compelling
    1. Biochemistry and Chemical Biology

    Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth

    Flavie Coquel, Sing-Zong Ho ... Philippe Pasero
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
    1. Evolutionary Biology

    Horizontally transferred cell-free chromatin particles function as autonomous “predatory” genomes and vehicles for transposable elements within host cells

    Soumita Banerjee, Soniya Shende ... Indraneel Mittra
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TPR is required for cytoplasmic chromatin fragment formation during senescence

    Bethany M Bartlett, Yatendra Kumar ... Wendy A Bickmore
    Evidence is provided suggesting that heterochromatin re-organisation during cell senescence can compromise the structural integrity of the nucleus, leading to activation of an inflammatory process.
    1. Cell Biology

    A fat-2(wa17) suppressor screen in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

    Delaney Kaper, Uroš Radović ... Marc Pilon
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Computational and Systems Biology

    Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

    Dylan C Sarver, Muzna Saqib ... G William Wong
    Mitochondrial respiration atlas reveals functional signatures of aging across diverse tissues and organ systems.
    1. Computational and Systems Biology

    Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

    Zhiwei Huang, Songhao Luo ... Jiajun Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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