Browse the search results

Monosomy in yeast results in numerous gene dosage insufficiencies with potentially lethal collective effect, but strong positive epistasis rooted in the modular structure of cell metabolism cancels it.

Chemotherapeutics altering DNA topology evoke RNA polymerase I inhibition, rDNA damage and consequent formation of PNAs that segregate persistent rDNA lesions from the active nucleolus, with implications for rDNA maintenance and design of new cancer treatment strategies targeting rDNA repair.

Mouse TRIP13 localizes to synapsed chromosomal axes and thus exhibits mutually exclusive localization with HORMAD1/HORMAD2, providing a cell biological explanation for dissociation of HORMAD1/2 from chromosomal axes upon synapsis.

An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.

Boundary:boundary pairing interactions drive TAD formation in Drosophila.

SCC3 not only functions as a member of cohesin complex but also participates in homologous pairing and synapsis during rice meiosis.

Subtelomeric sequences in the yeast S. cerevisiae are dispensable for either cell proliferation or homologous recombination-mediated telomere maintenance in telomerase-null cells, suggesting that these sequences represent remnants of genome evolution.