317 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

    Charlotte P Choi et al.
    snpc-1.3 specifies male piRNA transcription and is regulated by the sex determination pathway.
    1. Cell Biology
    2. Genetics and Genomics

    Aging: Unite to predict

    Meeraj Kothari, Daniel W Belsky
    Integrating the analysis of molecular data from different sources may improve our understanding of the effects of biological aging.
    Insight
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    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou et al.
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Cell Biology
    2. Genetics and Genomics

    An integrative study of five biological clocks in somatic and mental health

    Rick Jansen et al.
    An integrative study of five biological clocks in somatic and mental health indicate that one's biological age is best reflected by combining aging measures from multiple cellular levels.
    1. Physics of Living Systems
    2. Immunology and Inflammation

    Early life imprints the hierarchy of T cell clone sizes

    Mario U Gaimann et al.
    The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.
    1. Plant Biology

    A fungal member of the Arabidopsis thaliana phyllosphere antagonizes Albugo laibachii via a GH25 lysozyme

    Katharina Eitzen et al.
    A basidiomycete yeast closely related to fungal smuts is an antagonistic microbe in the Arabidopsis leaf phyllosphere that inhibits infection by Albugo laibachii via a GH25 hydrolase with lysozyme activity.
    1. Genetics and Genomics

    DNA damage—how and why we age?

    Matt Yousefzadeh et al.
    There is now sufficient and diverse evidence to support a cogent argument that DNA damage plays a causal role in aging.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Cell Biology
    2. Medicine

    Research: A new era for research into aging

    Matt Kaeberlein, Jessica K Tyler
    eLife is publishing a special issue on aging, geroscience and longevity to mark the rapid progress made in this field over the past decade, both in terms of mechanistic understanding and translational approaches that are poised to have clinical impact on age-related diseases.
    Editorial
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