275 results found
  1. May 2014

    Episode 12: May 2014

    In this episode we hear about the neuroscience of chewing, skin cancer, African sleeping sickness, an ancient protein complex, and our editor-in-chief shares his thoughts on scientific publishing.

  2. Episode 53: January 2019

    In this episode, we hear about memory consolidation, breast cancer, leafcutter ants, deep-sea biodiversity and the beneficial effects of oxytocin on our health.
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Impact of the scale-up of piped water on urogenital schistosomiasis infection in rural South Africa

    Frank Tanser et al.
    Scale-up of safe water supplies decreases a child's risk of urogenital schistosomiasis infection by eight-fold in a typical rural African population.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg et al.
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

    Shi Yun Yeo et al.
    Loss-of-function screening identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway and revealed that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two critical barriers that prevent oncogenic transformation.
    1. Developmental Biology

    Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut

    Erez Cohen et al.
    Ploidy-increasing endocycles may represent a tradeoff between loss of regenerative capacity and preservation of tissue architecture.
    1. Immunology and Inflammation

    The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes

    Yasmina Serroukh et al.
    The acquisition of cytotoxic function by human CD4 T cells is an integral part of the T helper 1 differentiation pathway and is limited by the transcription factor ThPOK.
    1. Developmental Biology

    The Wg and Dpp morphogens regulate gene expression by modulating the frequency of transcriptional bursts

    Rachael Bakker et al.
    Experimental results in Drosophila support a model in which gene expression is fundamentally controlled by morphogens tuning the same transcription parameter for genes that are expressed in highly diverse patterns.
    1. Chromosomes and Gene Expression

    High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

    Douglas Maya Miles et al.
    Ploidy is stably maintained in Saccharomyces cerevisae by a tight coordination between histone levels and cell cycle events.
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