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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

    Samuel T Coradetti et al.
    Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.
    1. Microbiology and Infectious Disease

    Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages

    Florence Caro et al.
    Ribosome profiling has bridged the knowledge gap between transcription and translation during malaria blood stage development and provided a comprehensive gene expression resource for this parasite.
    1. Evolutionary Biology

    Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity

    Jin Xu et al.
    Human cell lines regress to become ‘de-sexualized’ by reconfiguring to a 2:3 X/A ratio of high fitness, thus shedding light on the evolution of mammalian sex chromosomes.
    1. Immunology and Inflammation

    Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

    Naresh S Redhu et al.
    A detailed time-series analysis reveals that the interleukin-10 receptor prevents susceptibility to microbiota-driven colonic inflammation that emerges at the time of weaning by directly inhibiting the acquisition of a pro-inflammatory intestinal macrophage phenotype.
    1. Cancer Biology

    Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

    Paul A Clarke et al.
    Detailed molecular profiling investigations alongside antitumor testing and tolerability studies in animals suggest caution when considering the clinical development of inhibitors of CDK8 and CDK19, since a clear therapeutic window could not be demonstrated with two structurally distinct, potent and selective prototype drugs.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

    Hiroshi Yamaguchi et al.
    Zebrafish genetics and cryo-electron tomography reveal distinct roles of all vertebrate PIH family proteins in axonemal dynein assembly and cilia/flagella motions, assigning specific dynein subtypes to each PIH protein.
    1. Chromosomes and Gene Expression

    Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

    Nicola Manfrini et al.
    The conversion of the ends of a double-strand break from double-stranded to single-stranded DNA, which is necessary to initiate homologous recombination, is responsible for loss of transcription and RNA polymerase occupancy around the double-strand break in Saccharomyces cerevisiae.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

    Jihoon Shin et al.
    The regulation of the core transcription factor Oct4 by the Aurkb-PP1 axis links the cell cycle to pluripotency programs in embryonic stem cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

    Andrey Poleshko et al.
    The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

    Birong Shen et al.
    Accumulation of mutations in some cancers is correlated with an aberration of DNA repair and access of a DNA deaminase to normal genomic DNA.