Computational analysis of MNase-seq data reveals that alternatively positioned nucleosomes are prevalent in both yeast and human cells and create significant heterogeneity within cell populations.

Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.

Mechanistic, trait-based models for transmission of West Nile virus and observed incidence of human West Nile disease cases in the US both show optimal transmission at 24-25°C.

Structures of multiple states of two dicarboxylate transporters explain the conformational changes needed for substrate import.

Simple mathematical models can relate gene expression to climatic variables in field grown rice.

Human telomerase unfolds and extends parallel G-quadruplexes using a unique mechanism involving its RNA template.

Whereas in a paradigmatic structure an SM protein chaperone clamps its client SNARE shut, a second structure demonstrates that an SM protein can also hold its SNARE open to promote assembly.

Variation in autumnal expression from starting expression levels and initial cold-down-regulation, rather than epigenetic silencing, is the major field variable conferred by worldwide haplotypes of the floral repressor gene, FLC.

Human vitamin K epoxide reductase (VKOR) has a four transmembrane domain topology that supports the use of a homology model, enabling identification of active site residues and human variant impact.

The tethering complex HOPS employs affinity for each of the 4 SNAREs to catalyze assembly of 3-SNARE intermediates, supporting an immediate burst of membrane fusion triggered by the 4th SNARE.