542 results found
    1. Biochemistry and Chemical Biology

    Stepwise assembly of the human replicative polymerase holoenzyme

    Mark Hedglin, Senthil K Perumal ... Stephen Benkovic
    Fluorescence resonance energy transfer has been used to explore the interactions between DNA polymerases, sliding clamps and clamp loaders as DNA is replicated in human cells.
    1. Cell Biology
    2. Neuroscience

    Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

    Moritz Armbruster, Mirko Messa ... Timothy A Ryan
    The recycling of transmitter vesicles at synapses shows calcium-dependent regulation that depends on the phosphorylation status of an enzyme called dynamin.
    1. Cell Biology
    2. Neuroscience

    UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans

    Zhitao Hu, Xia-Jing Tong, Joshua M Kaplan
    Long and short variants of a protein called UNC-13, assisted by another called Tomosyn, regulate the timing of synaptic vesicle release in C. elegans.
    1. Neuroscience

    Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions

    Shigeki Watanabe, Qiang Liu ... Erik M Jorgensen
    Optogenetics has revealed that synaptic vesicles can be recycled extremely rapidly in nematodes, indicating that existing models for how synapses 'reload' may need to be revised.
    1. Neuroscience

    Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics

    Keming Zhou, Tamara M Stawicki ... Yishi Jin
    The precise position of UNC-13 at the active zone near a synapse depends on the N-terminus of the protein, and the C2A domain in particular, and is essential for accelerating neurotransmitter release.
    1. Neuroscience

    Long term functional plasticity of sensory inputs mediated by olfactory learning

    Nixon M Abraham, Roberto Vincis ... Alan Carleton
    Associative learning, but not passive odorant exposure, induces a novel long lasting functional plasticity in the periphery of mouse olfactory system, making previously encountered odors easier to detect in the future.
    1. Stem Cells and Regenerative Medicine

    In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

    Weida Li, Mio Nakanishi ... Qiao Zhou
    Combinations of transcription factors can convert pancreatic acinar cells into endocrine α-, β- and δ-cells in vivo.
    1. Cell Biology
    2. Plant Biology

    Abscisic acid dynamics in roots detected with genetically encoded FRET sensors

    Alexander M Jones, Jonas ÅH Danielson ... Wolf B Frommer
    Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

    Xiaofei Jia, Erin Weber ... Yong Xiong
    HIV-1 viral protein u (Vpu) can stimulate novel versions of canonical interactions with the clathrin adaptor AP1 to counteract the host antiviral protein BST2.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

    Braden T Lobingier, Daniel P Nickerson ... Alexey J Merz
    Sec1/Munc18 (SM) proteins shield SNARE complexes from NSF/Sec18-mediated disassembly through cooperative binding interactions with SNARE complexes and the universal co-chaperone α-SNAP/Sec17.

Refine your results by:

Type
Research categories