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AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.

Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.

Lineage-specific regulatory loops involving evolutionarily conserved myogenic Transcription Factors control muscle identity specification in Drosophila.

Mechanical stress promotes the expression of the homeobox gene and meristem master regulator STM, synergistically and independently from auxin depletion.

Heterochromatin proteins compartmentalize DNA into compact structures resistant to mechanical disruption but susceptible to competitive dissolution.

A bnAb derived from a case of HIV superinfection has distinct qualities from other HIV-specific bnAbs, including framework residues that contribute to neutralization breadth and a unique viral escape profile.

The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.

Polycomb repressive complex 1.1 restricts precocious myeloid differentiation of hematopoietic stem/progenitor cells and expansion of myeloid progenitors, thereby serving as a gatekeeper of emergency myelopoiesis and myeloid transformation.