64 results found
    1. Cell Biology
    2. Neuroscience

    KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring

    Noriko Homma et al.
    Postnatal KIF2A is a key regulator for axon/dendrite determination of developing dentate granule cells, and its loss developed apical axons in dentate molecular layer, broke hippocampal wiring, and induced temporal lobe epilepsy.
    1. Human Biology and Medicine
    2. Neuroscience

    Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

    Philipp Janz et al.
    Non-invasive imaging of hippocampal neurodegeneration and structural reorganization during epileptogenesis allows the prediction of disease severity in mesial temporal lobe epilepsy, which may facilitate the early pharmacological intervention before seizure onset.
    1. Human Biology and Medicine
    2. Neuroscience

    MRI: Searching for epilepsy’s crystal ball

    Olli Gröhn, Alejandra Sierra
    Multi-modal MRI techniques have identified biomarkers that could help to predict whether someone will develop epilepsy.
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    1. Computational and Systems Biology
    2. Neuroscience

    A model for focal seizure onset, propagation, evolution, and progression

    Jyun-you Liou et al.
    Usage-dependent inhibition breakdown and neural adaptation underpins the key spatiotemporal dynamics of human focal seizures.
    1. Neuroscience

    A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval

    Melissa Hebscher et al.
    Inhibitory noninvasive stimulation to the precuneus disrupts theta and gamma oscillatory coupling between medial temporal lobes and neocortical regions during complex personal memory retrieval.
    1. Neuroscience

    Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

    Stephanie C Seeman et al.
    A high-throughput pipeline for the characterization of cortical connectivity in mouse and human cortex.
    1. Neuroscience

    Phase-tuned neuronal firing encodes human contextual representations for navigational goals

    Andrew J Watrous et al.
    Prospective navigational goals are represented by single neuron firing rates and firing relative to slow oscillatory phase (phase coding) in the human medial temporal lobe.
    1. Neuroscience

    The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

    Laura A Ewell et al.
    A novel framework for separating normal and pathological high-frequency oscillations in animals with epilepsy uncovers new mechanisms for impaired hippocampal network function.
    1. Neuroscience

    Biophysics of object segmentation in a collision-detecting neuron

    Richard Burkett Dewell, Fabrizio Gabbiani
    Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity for escaping an impending threat.
    1. Computational and Systems Biology
    2. Neuroscience

    Multivariate stochastic volatility modeling of neural data

    Tung D Phan et al.
    Multivariate stochastic volatility models provide insights into understanding the dynamics and connectivity of neural signals during cognitive tasks.

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