11 results found
    1. Cell Biology
    2. Developmental Biology

    Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming

    Ke Xu et al.
    Spatial and temporal cues intersect, likely via enhancer-promoter looping, to turn on a master identity switch that in turn dictates natural lineage reprogramming with high efficiency and temporospatial precision.
    1. Neuroscience

    A Matlab-based toolbox for characterizing behavior of rodents engaged in string-pulling

    Samsoon Inayat et al.
    Analysis methods for video data of rodents engaged in string-pulling behavior have been developed and used to highlight differences in motion profiles of Swiss Webster and C57Bl/6 mice.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq

    Pingzhu Zhou et al.
    A method for measuring p300 chromatin occupancy in specific lineages of mouse tissues was used to map endothelial enhancers and to identify previously unrecognized angiogenesis-related sequence motifs.
    1. Developmental Biology

    Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates

    Michael W Susman et al.
    Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.
    1. Neuroscience

    Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

    Kevin P Koster et al.
    NMDA receptor function is regulated by protein depalmitoylation during visual cortical maturation and is dysfunctional in infantile neuronal ceroid lipofuscinosis.
    1. Cell Biology
    2. Developmental Biology

    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli

    Michael H Hayes et al.
    The equilibrium between solubility and aggregation of proteins in the nucleus is controlled by co-aggregates like RNA and the action of ATP as both an energy source and a destabilizing chemical agent.
    1. Developmental Biology

    SMOC can act as both an antagonist and an expander of BMP signaling

    J Terrig Thomas et al.
    SMOC inhibits BMP signaling locally, but also expands the range of BMP signaling by competing for heparan sulfate binding sites.
    1. Developmental Biology
    2. Neuroscience

    NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

    Janelle C Leggere et al.
    Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.
    1. Immunology and Inflammation

    Capturing change in clonal composition amongst single mouse germinal centers

    Daniel J Firl et al.
    Repeated interrogation of single germinal centers in vivo reveals a more fluid landscape than expected and unlocks new lines of investigation.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo

    Kai Xie et al.
    An implantable device based on organic electrochemical transistors is developed for quantitative mapping of neurotransmitter release across multiple brain regions, revealing a cross-talk between the mesolimbic and nigrostriatal dopaminergic pathways.

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