Biochemical and genetic tests have revealed that a liver protein called NTCP is a functional receptor for hepatitis B and D viruses, which should lead to an improved understanding of the infections caused by these viruses and assist the development of new intervention strategies.

Cleavage of a membrane-bound transcription factor by the chemotherapeutic reagent doxorubicin can block the proliferation of tumor cells.

COPII vesicles regulate the metabolism of cholesterol through the selective transport of secretory proteins.

Skin cells from a patient with retinitis pigmentosa have been used to generate induced pluripotent stem cells, which could potentially form the basis of new treatments for this disease.

Cells from vertebrate and invertebrate model systems can be reprogrammed into stem-like cells using mouse genes.

The soluble cargo protein albumin traverses the Golgi stack at much faster rates than procollagen aggregates, by diffusion via intercisternal continuities.

An immune system pattern recognition receptor potentiates anti-tumor innate immune responses, offering new insight into anti-tumor activity of the innate immune system.

A previously unrecognized transcriptional coactivator function of the dyskerin ribonucleoprotein complex and its associated small nucleolar RNA has been uncovered and mediates embryonic stem cell-specific transcription.

Lrp4 mutant mice display profound deficits in cognitive tasks that assess learning and memory with disruptions in the subcellular organization of synaptic inputs and synaptic plasticity in the hippocampus.