A novel statistical framework and approach using sibling phenotype pairs allows inference of genetic architecture in the tails of complex traits to be made without genetic data.
Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
Fridtjof Brauns, Nikolas H Claussen ... Boris I Shraiman
Active and passive contributions to cell shape change and rearrangements can be distinguished from observed cell geometry, revealing the self-organization mechanisms underlying internally-driven epithelial convergent extension.
Theoretical and experimental evidence that Hh signaling dynamics balances robust positioning and sharpness of different target genes in the Drosophila wing disc.
Attentional modulation is affected by target-distractor similarity, indicating tuning sharpening as the underlying mechanism for response enhancement during object-based attention.
An accurate and efficient biologically plausible statistical model of the spiking activity of neural populations shows computational benefits of homeostatic synaptic scaling in learning large neural population codes.
Priya M Christensen, Jonathan Martin ... Kelli L Palmer
A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.
Ariel Zylberberg, Akram Bakkour ... Michael N Shadlen
The subjective value of choice options changes during deliberation, and accounting for these changes improves predictions of choices, response times, and BOLD fMRI activity.
