1,635 results found
    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.
    1. Immunology and Inflammation

    Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

    Jialong Yang et al.
    Genetic ablation of Raptor and Rictor in mice revealed critical roles of mTORC1 and mTORC2 in T follicular helper cell differentiation and germinal center responses.
    1. Developmental Biology
    2. Neuroscience

    Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition

    Shalini Singh et al.
    Neuronal progenitor cells autonomously inhibit polarization via the transcription factor Zeb1.
    1. Stem Cells and Regenerative Medicine

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation

    Li Li et al.
    Proteasome-mediated degradation of the TATA-box binding protein (TBP) during terminal differentiation is regulated by the E3 ligase Huwe1 and the deubiquitinase USP10.
    1. Immunology and Inflammation

    The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets

    Takuya Koike et al.
    Unveiling a mechanism for the fate decision of B-cell differentiation into two functionally distinct memory B cell subsets.
    1. Neuroscience

    Motoneuron Wnts regulate neuromuscular junction development

    Chengyong Shen et al.
    A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

    Shuping Zhang et al.
    The heme and HRI-mediated eIF2aP–ATF4 integrated stress response in erythropoiesis has a major global impact, especially under the stress condition of iron deficiency.
    1. Developmental Biology
    2. Neuroscience

    Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain

    Akiko Terauchi et al.
    Feedback signaling between the synapse and nucleus via FGF22 and IGF2 directs the activity-dependent stabilization of presynaptic terminals in the mouse hippocampus.

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