Mutagenesis and activity assays in vitro and in vivo identify residues in the tethered agonist of GPR116, as well as those within the extracellular loops, that are critical for mediating the response to the tethered agonist.

Latrophilin-2 G protein coupling is required in axons but not target neurons for neural circuit assembly in the mouse hippocampus.

Heterozygous Nf1 knockout mice exhibit distinct dopaminergic phenotypes in vivo, as revealed by the genetically encoded dopamine sensor dLight1, patch clamp electrophysiology, optogenetics, and novel viral tools for morphological analysis.

Eutherian CD4 evolved counterbalancing motifs in the extracellular, transmembrane, and intracellular domains that regulate CD4⁺ T cell responses to peptide antigens presented by class II MHC (pMHCII).

Structural dynamic insights revealed the mechanisms of PC1 activation by stalk-derived peptide agonists which can form a foundation for development of PC1 as a therapeutic target for ADPKD treatment.

An interdisciplinary approach uncovers a new antinociceptive molecular mechanism and shows that the adhesion GPCR CIRL adjusts the sensation of gentle touch and noxious mechanical insult in opposite directions.

Metabotropic mechanosensing occurs through an adhesion-type G protein-coupled receptor.

L-amino acids are agonists of calcium-sensing receptor, and act jointly with calcium and phosphate ions to control receptor function.

TRACC (Transcriptional Readout Activated by Cell-cell Contacts) is an engineered molecular tool that detects and records cell-cell contacts in mammalian systems.

EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.