216 results found
    1. Genes and Chromosomes
    2. Plant Biology

    A quantitative hypermorphic CNGC allele confers ectopic calcium flux and impairs cellular development

    David M Chiasson et al.
    A mutant allele encoding a deregulated subunit of an ion channel tetramer revealed a mechanistic connection between protein heteromerization and quantitative genetic behavior.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

    Paul Victor Sauer et al.
    The CAF1 complex binds single histone H3-H4 dimers, and two such complexes associate with extended DNA elements to ensure the deposition of H3-H4 tetramers, the first step in the assembly of nucleosomes.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Motor Proteins: A surprising twist

    Nikta Fakhri, Christoph F Schmidt
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    1. Biochemistry
    2. Genes and Chromosomes

    Chromatin: Assembly, remodelled

    Karim Bouazoune, Robert E Kingston
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    1. Biochemistry

    Protein Kinases: What is the point of pseudokinases?

    Saravanan Raju, Andrey S Shaw
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    1. Cell Biology
    2. Human Biology and Medicine

    Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

    Nuno Rocha et al.
    Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.
    1. Biophysics and Structural Biology

    Molecular architecture of the 90S small subunit pre-ribosome

    Qi Sun et al.
    The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu et al.
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.
    1. Genes and Chromosomes
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim et al.
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.

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