437 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

    Oliver J Wilkinson et al.
    Structural and biochemical analysis of human CtIP provides new insights into DNA break recognition, binding and bridging during homologous recombination.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    A quantitative hypermorphic CNGC allele confers ectopic calcium flux and impairs cellular development

    David M Chiasson et al.
    A mutant allele encoding a deregulated subunit of an ion channel tetramer revealed a mechanistic connection between protein heteromerization and quantitative genetic behavior.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

    Paul Victor Sauer et al.
    The CAF1 complex binds single histone H3-H4 dimers, and two such complexes associate with extended DNA elements to ensure the deposition of H3-H4 tetramers, the first step in the assembly of nucleosomes.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Chromatin: Assembly, remodelled

    Karim Bouazoune, Robert E Kingston
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Motor Proteins: A surprising twist

    Nikta Fakhri, Christoph F Schmidt
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    1. Biochemistry and Chemical Biology

    Protein Kinases: What is the point of pseudokinases?

    Saravanan Raju, Andrey S Shaw
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    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Immunology and Inflammation

    Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

    Rebeca Jimeno et al.
    The tissue environment shapes the lipid recognition capacity of natural killer T cells.
    1. Structural Biology and Molecular Biophysics

    Structural basis for ion selectivity in TMEM175 K+ channels

    Janine D Brunner et al.
    Structural and functional analysis of a recently discovered non-canonical potassium channel family reveals a unique selectivity filter that is exposed to permeating ions only in the conductive state.

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