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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4

    Christopher I Murray et al.
    The IKs potassium channel complex displays functional flexibility that depends on the ratio of its constituent KCNQ1 and KCNE1 protein subunits.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    eIF2B conformation and assembly state regulate the integrated stress response

    Michael Schoof et al.
    eIF2-P activates the integrated stress response by inducing a conformational change in eIF2B that decreases substrate (eIF2) binding and reduces eIF2B's catalytic activity.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure of the human core transcription-export complex reveals a hub for multivalent interactions

    Thomas Pühringer et al.
    The cryo-EM structure of the human transcription-export THO–UAP56 complex reveals mechanisms of mRNA nuclear export licensing.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    A quantitative hypermorphic CNGC allele confers ectopic calcium flux and impairs cellular development

    David M Chiasson et al.
    A mutant allele encoding a deregulated subunit of an ion channel tetramer revealed a mechanistic connection between protein heteromerization and quantitative genetic behavior.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains

    Huaying Zhao et al.
    Members of kainate and AMPA families of glutamate receptors exhibit large differences in affinity for homo- and hetero-dimerziation of their amino terminal domains, which may control gating characteristics and ion selectivity of receptor subtypes with different subunit composition.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular model for the role of SYCP3 in meiotic chromosome organisation

    Johanna Liinamaria Syrjänen et al.
    A structural and biochemical study of human SYCP3 provides the first molecular model for the three-dimensional organisation that is imposed upon chromosomal DNA during meiosis and is essential for genetic exchange and fertility.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

    Inna Rozman Grinberg et al.
    Structural and functional characterization of an unanticipated mode of allosteric activity regulation in ribonucleotide reductases controlled by an ATP-cone in the radical-generating subunit.
    1. Structural Biology and Molecular Biophysics

    Molecular structures of the human Slo1 K+ channel in complex with β4

    Xiao Tao, Roderick MacKinnon
    The structures of Slo1 in complex with b4 imply that the auxiliary beta subunits modulate the channel's gating properties through stabilizing ‘pre-existing’ conformations rather than creating new ones.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells

    Diana Gumber et al.
    Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

    Bishnu P Paudel et al.
    Human telomerase unfolds and extends parallel G-quadruplexes using a unique mechanism involving its RNA template.