Newly formed tetraploid cells rapidly lose extra centrosomes acquired upon tetraploidization via asymmetric centrosome clustering during cell division and selective advantage of tetraploid daughter cells that inherit a single centrosome.

Mouse genetic manipulations reveal that Cables2 is involved in the progress of gastrulation by interacting with Wnt/β-catenin and the p53 pathways in diminished Rps21 expression.

A ménàge à trois introduces extra DNA only to plant embryos, thus skipping endosperm-induced seed hybridization barriers.

Mitochondrial fusion enables a metabolic transition during spermatogenesis.

Aneuploidy can cause chromosome mis-segregation and specific cellular phenotypes driven by expression of genes on the extra chromosome.

The protozoan parasite Trypanosoma brucei gambiense has undergone recent clonal evolution that reveals the theoretically predicted Meselson effect at a genome-wide level.

Terminally differentiated neurons and glia can re-enter the cell cycle to become polyploid in the adult fly brain, to protect cells from DNA damage-associated death.

Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.

Dosage-compensated gene expression facilitates chromosomal aneuploidy, which presents a rapid route to phenotypic evolution in natural yeast isolates.

The retinoblastoma tumor suppressor regulates cell cycle progression when it's in 14 mono-phosphorylated isoforms.