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    1. Neuroscience

    Spatiotemporal constraints on optogenetic inactivation in cortical circuits

    Nuo Li et al.
    Electrophysiology measurements characterized eight optogenetic methods, including a new reporter mouse expressing soma-localized light-activated chloride channels, for inactivating small regions of mouse neocortex.
    1. Neuroscience
    2. Physics of Living Systems

    Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia

    Andrew R McKinstry-Wu et al.
    Responses to anesthetics differ among individuals and fluctuate stochastically despite constant drug concentration, however, the amount of noise driving transitions between the responsive and the unresponsive state is conserved.
    1. Neuroscience

    An image-computable model for the stimulus selectivity of gamma oscillations

    Dora Hermes et al.
    Gamma-band oscillations show striking differences in stimulus selectivity compared to fMRI and broadband field potentials in human visual cortex, and are explained by a novel, image-computable model.
    1. Neuroscience

    Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

    Christopher W Mount et al.
    Oligodendrocyte precursor cells receive brain-wide, circuit-specific intracortical, coritcocortical and thalamocortical synaptic inputs.
    1. Neuroscience

    HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

    Niklas Byczkowicz et al.
    The cAMP-HCN pathway can control action potential conduction velocity providing neuromodulators with the ability to tune energy consumption and temporal delays across axons in the brain.
    1. Neuroscience

    An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway

    Sho Aoki et al.
    A novel connection from ventral striatum to motor cortex enables emotion and motivation to influence action and motor control.
    1. Neuroscience

    Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1

    Amy M LeMessurier et al.
    Sensory enrichment creates a more columnar, less salt-and-pepper whisker map in somatosensory cortex, showing that impoverished experience contributes to intermixed tuning in rodent sensory maps.
    1. Neuroscience

    Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory

    Matthew M Nour et al.
    Striatal dopamine 2/3 receptor (D2/3R) availability is related to working memory-induced functional connectivity changes in the default mode network, and this mediates the relationship between D2/3Rs and task performance.
    1. Developmental Biology
    2. Neuroscience

    FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

    Ryan J Kast et al.
    Foxp2 is dispensable for several features of cortical development that were previously considered to depend on its function.
    1. Neuroscience

    Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats

    Briac Halbout et al.
    Inhibiting ventral tegmental dopamine neurons, or their inputs to nucleus accumbens, disrupts cue-motivated reward seeking in a manner that depends on the microstructure of behavior.