2,082 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Bistability of a coupled Aurora B kinase-phosphatase system in cell division

    Anatoly V Zaytsev, Dario Segura-Peña ... Ekaterina L Grishchuk
    Self-activating Aurora B kinase, opposed by an inhibitory phosphatase, forms spatial phosphorylation patterns during cell division.
    1. Ecology
    2. Physics of Living Systems

    Particle foraging strategies promote microbial diversity in marine environments

    Ali Ebrahimi, Akshit Goyal, Otto X Cordero
    An ecological trade-off between growth and death enables microbes with different dispersal strategies to coexist on particulate matter in the oceans.
    1. Computational and Systems Biology

    Environmental fluctuations reshape an unexpected diversity-disturbance relationship in a microbial community

    Christopher P Mancuso, Hyunseok Lee ... Ahmad S Khalil
    Laboratory experiments using a microbial community and mathematical modeling reveal how environmental disturbances can predictably alter the diversity and composition of an ecosystem.
    1. Neuroscience

    Complementary congruent and opposite neurons achieve concurrent multisensory integration and segregation

    Wen-Hao Zhang, He Wang ... Si Wu
    Opposite neurons in multisensory areas compute the cue disparity information essential for information segregation.
    1. Developmental Biology

    Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo

    Jacques P Bothma, Hernan G Garcia ... Michael Levine
    Quantitative live imaging assays reveal that multiple enhancers often fail to work in an additive fashion in the patterning of the Drosophila embryo, and sometimes even interfere with one another.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu, Ri-Qi Su ... Xiao Wang
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

    William Duncan Martinson, Rebecca McLennan ... Philip K Maini
    Data-driven mathematical modeling suggests that leading neural crest cells in a moving stream can robustly communicate with trailing cells by remodeling their extracellular matrix, thereby enabling long-distance collective migration.
    1. Neuroscience

    Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

    Yoav Ger, Moni Shahar, Nitzan Shahar
    Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston, Joerg P Burgstaller ... Nick S Jones
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Genetics and Genomics

    Utility of polygenic embryo screening for disease depends on the selection strategy

    Todd Lencz, Daniel Backenroth ... Shai Carmi
    Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.

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