1,128 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Bistability of a coupled Aurora B kinase-phosphatase system in cell division

    Anatoly V Zaytsev et al.
    Self-activating Aurora B kinase, opposed by an inhibitory phosphatase, forms spatial phosphorylation patterns during cell division.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek et al.
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
    1. Neuroscience

    Inhibition stabilization is a widespread property of cortical networks

    Alessandro Sanzeni et al.
    The strongly coupled theoretical regime describes the function of mouse sensory and motor cortical areas.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Multiple sources of slow activity fluctuations in a bacterial chemosensory network

    Remy Colin et al.
    Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Asynchrony between virus diversity and antibody selection limits influenza virus evolution

    Dylan H Morris et al.
    Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Mechanics and dynamics of translocating MreB filaments on curved membranes

    Felix Wong et al.
    Principal curvature-dependent motion of bacterial actin MreB results in localization consistent with all known literature.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips et al.
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Neuroscience

    Complementary congruent and opposite neurons achieve concurrent multisensory integration and segregation

    Wen-Hao Zhang et al.
    Opposite neurons in multisensory areas compute the cue disparity information essential for information segregation.
    1. Ecology

    Migration confers winter survival benefits in a partially migratory songbird

    Daniel Zúñiga et al.
    Testing of fitness-related benefits in migratory population of European blackbirds offers confirming predictions of theoretical models on the evolution and maintenance of migration.

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