Combining experimental and theoretical approaches reveals the interplay between optogenetic manipulation and recurrent interactions in mouse cortex.

Mathematical modeling suggests that grid cells in the rodent brain use fundamental principles of number theory to maximize the efficiency of spatial mapping, enabling animals to accurately encode their location with as few neurons as possible.

A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.

Gender-bias in peer reviewing might persist even when gender-equity is reached because both male and female editors operate with a same-gender preference whose characteristics differ by editor-gender.

Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.

What can authors and reviewers do to keep common statistical mistakes out of the literature?

Two theoretical studies reveal how networks of neurons may behave during reward-based learning.

The Reproducibility Project: Cancer Biology will generate a high-quality dataset to explore questions about the reproducibility of research, and will make all data, analysis and other research materials openly available to the research community.

The deer mouse (Peromyscus) has emerged as a model system for studying many aspects of biology, supported by extensive historical knowledge of its fascinating and varied natural history.