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    1. Neuroscience

    MDN brain descending neurons coordinately activate backward and inhibit forward locomotion

    Arnaldo Carreira-Rosario et al.
    A brain descending interneuron can coordinate a switch between two antagonistic behaviors (forward and backward locomotions).
    1. Neuroscience

    Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome

    Anton Miroschnikow et al.
    A parallel neuronal network architecture ensures control of basic feeding reflex circuits via integration of crossmodal sensory information to filter multiple biological events and enhance meaningful behavioral choice.
    1. Microbiology and Infectious Disease

    Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

    Saurabh Mishra et al.
    Intrinsic tolerance of Mycobacterium tuberculosis toward the world's most successful antibacterials, β-lactams, is dependent on cytoplasmic redox potential and an intracellular redox-sensor WhiB4.
    1. Neuroscience

    RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

    Marisa M Brockmann et al.
    The active zone scaffold protein RIM-BP2 performs distinct functions in vesicle release at two hippocampal synapses, providing insights on how synapses express diversity in release properties.
    1. Cell Biology
    2. Immunology and Inflammation

    PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

    Graham J Britton et al.
    T cell receptor and Notch signaling pathways are linked via a novel mechanism involving modulation of the cytoskeleton.
    1. Cancer Biology

    Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

    Ernesto Pérez et al.
    The oncogenic RasV12 keeps cells mutant for the tumor suppressor scribble in an undead-like condition, which is required for an amplification loop that promotes tumorigenesis.
    1. Neuroscience

    A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

    Yuwei Yao et al.
    A cell-surface receptor called Gpr52 is able to lower the levels of the disease-causing protein mutant huntingtin and suppress its toxicity when knocked-down, making this receptor a promising drug target in Huntington's disease.
  1. Announcing the next phase of Executable Research Articles

    eLife and Stencila renew their partnership to make Executable Research Articles accessible to even more researchers and publishers.
  2. Media coverage: August roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in August 2017, including The National, Scientific American and New York Post.
  3. eLife Ambassadors: Programme teeming with activity after first quarter

    At only three months into the programme, eLife Ambassadors are already working on more than 20 distinct initiatives.