109 results found
    1. Cell Biology

    An alternative splicing program promotes adipose tissue thermogenesis

    Santiago Vernia et al.
    NOVA pre-mRNA spacing factors suppress adipose tissue energy expenditure.
    1. Genetics and Genomics

    Enhanced stability and polyadenylation of select mRNAs support rapid thermogenesis in the brown fat of a hibernator

    Katharine R Grabek et al.
    In the torpid hibernator, when transcription is inhibited, enhanced stability and polyadenylation explain increased abundance of crucial transcripts required for intense non-shivering thermogenesis during arousal.
    1. Biochemistry and Chemical Biology

    Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

    Vanja Panic et al.
    Mitochondrial pyruvate transport is required for brown fat thermogenesis.
    1. Biochemistry and Chemical Biology

    AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

    Sandra Galic et al.
    A single mutation in acetyl-CoA carboxylase blocking AMPK regulation inhibits food intake in mice in response to cold exposure or fasting causing them to lose weight.
    1. Cell Biology
    2. Developmental Biology

    Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

    Danielle Yi et al.
    Dot1l and its H3K79 methyltransferase activity are required for thermogenesis, and Dot1l is recruited by Zc3h10 to its targets genes to alter chromatin accessibility to activate the thermogenic gene program.
    1. Neuroscience

    mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

    Luke K Burke et al.
    AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.
    1. Cell Biology

    Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

    Prashant Rajbhandari et al.
    Crosstalk between IL10-producing immune cells and adipocytes within adipose tissue is an important determinant of thermogenesis and systemic energy balance.
    1. Stem Cells and Regenerative Medicine

    ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

    Wieneke Dijk et al.
    During sustained cold exposure, lipid fuel is specifically directed towards brown adipose tissue, but not white adipose tissue, via cold-induced regulation of Angiopoietin-like 4 (ANGPTL4).
    1. Neuroscience

    Cold-induced hyperphagia requires AgRP neuron activation in mice

    Jennifer D Deem et al.
    A combination of neuroscience approaches and indirect calorimetry demonstrate a physiological role for AgRP neurons in cold-induced hyperphagia and strongly suggest temperature is an important regulator of AgRP neuron activity.
    1. Cell Biology

    Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever

    Takeshi Yoneshiro et al.
    Genetic and cellular studies in rodents found branched-chain amino acids are critical nutrients that are transported and oxidized in the mitochondria through their carrier MBC for optimal febrile responses.

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