Cnidarian stinging cells use a specialized voltage-gated calcium channel to integrate distinct sensory signals and selectively trigger a predatory response.
Cryo-electron microscopic structures of 5-HT3A receptor in complex with first and second generations of clinically used setron reveal the molecular basis for their binding modes and mechanisms of inhibitory action.
Expression of a Dravet syndrome-associated mutation in inhibitory neurons disrupts activity of brainstem respiratory neurons and diminishes respiratory behavior in conjunction with seizures and premature death.
Genes implicated in the control of mammalian puberty function as components of a molecular clock that determines the timing of sexual differentiation in the C. elegans nervous system.
Specific attachment of molecularly defined gold nanoparticles enables precise localization, critical for structural studies in vivo, of proteins of unknown structure within the cellular milieu by cryo-electron tomography.
Hygroreception, a poorly understood process critical to insect survival, depends on a small protein in the antenna of the fruit fly that was previously thought to transport odorants.
In multi-channel sensory systems, gain adaptation can help maintain not only coding capacity across changes in signal intensity, but also combinatorial representations of odor identity.
Noise in a signaling network comprising thousands of molecules shapes diversity across cell populations and generates giant temporal fluctuations at the single-cell level.
