227 results found
    1. Neuroscience

    Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans

    Huiling Tan et al.
    Patterns of coordinated activity in the basal ganglia predict how much force we will use to grip objects, suggesting that individuals with paralysis may ultimately be able to use these signals to control graded responses in robotic devices.
    1. Neuroscience

    Multiplexed coding by cerebellar Purkinje neurons

    Sungho Hong et al.
    Cerebellar Purkinje neurons use a multiplexed simple spike code combining synchrony/spike time and firing rate, with each component encoding distinct information about movements such as motion onset timing and kinematics.
    1. Neuroscience

    Vocal development in a Waddington landscape

    Yayoi Teramoto et al.
    An integrated landscape framework shows how the coordinated changes in vocal apparatus, muscles, nervous system, and social interaction together influence the trajectory of vocal development.
    1. Structural Biology and Molecular Biophysics

    The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel

    Hai Li et al.
    Substrate-induced structural changes in GtACR1 provide new insight into the chemical mechanism of natural light-gated anion conductance and facilitate its optimization for photoinhibition of neuron firing in optogenetics.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

    Tatiana Kent et al.
    Polymerase θ is among the most proficient terminal transferases known and switches between three different mechanisms of terminal transferase activity.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter et al.
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Neuroscience

    Network dynamics underlying OFF responses in the auditory cortex

    Giulio Bondanelli et al.
    Computational modeling demonstrates that population dynamics of neural calcium activity following stimulus offset are consistent with a network mechanism based on recurrent interactions.
    1. Neuroscience

    Metal microdrive and head cap system for silicon probe recovery in freely moving rodent

    Mihály Vöröslakos et al.
    A reusable system of 3D printed stainless steel microdrive and plastic head cap allows stable recording of electrophysiological data in mice and rats and easy recovery of silicon probes.
    1. Computational and Systems Biology

    The structural connectome constrains fast brain dynamics

    Pierpaolo Sorrentino et al.
    The fast spreading of neural activity across the brain has a complex structure, imposed by the white-matter bundles.
    1. Neuroscience

    Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

    Trisha V Vaidyanathan et al.
    Cortical astrocytes play key roles in NREM sleep by regulating sleep depth and duration through separate GPCR pathways, and differentially control neuronal slow-wave activity in local and remote cortical circuits.

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